Advantages of controlled- and sustained-release systems for pulmonary drug delivery

 



  To treat both local and systemic lung diseases, pulmonary drug delivery (PDD) systems were recently introduced into the pharmaceutical field. PDD systems have been shown to deliver drugs directly to the required site in the body or to other distant sites via the bloodstream.

  Drugs are delivered to the lungs via pulmonary drug delivery systems to treat diseases of the respiratory tract. Because of the non-invasive technique, high blood circulation, large surface area for absorption, and permeability rate, this route is widely preferred. The growth is expected to be driven by an increase in the prevalence of chronic diseases such as bronchitis, tuberculosis, and chronic obstructive pulmonary disease, limitations of traditional treatments for pulmonary delivery, better penetrability of the drug, minimum dosage requirement, technological advancements, and an increase in smoking.

 

What is the definition of pulmonary administration?

The pulmonary route of administration represents local/regional drug delivery for a variety of lung and respiratory diseases, such as asthma and cystic fibrosis. Drugs have been attempted to enter the body through the lungs, but with limited success, as in the case of inhaled insulin or calcitonin.

 

What are the benefits of pulmonary drug delivery systems in pulmonary disease treatment?

The advantages of controlled- and sustained-release pulmonary drug delivery systems include lower drug doses, improved therapeutic efficiency, improved patient compatibility, quick onset of action, bypassing hepatic metabolism, localized delivery, reduced systemic side effects, prolonged action, and lower costs.

 

  Oral drug delivery can be replaced with pulmonary drug delivery. Due to systemic administration via fast absorption by the alveolar region, pulmonary drug delivery is primarily beneficial for the treatment of respiratory diseases. The development of simple, cost-effective, and easy-to-use pulmonary drug delivery devices is critical.

   These devices are made to help with consistent drug delivery, increased lung penetration, and multi-dosing options. Manufacturers are currently focusing their efforts on the development of small, portable devices that encourage patient compliance.

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