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Streptozocin; a Class of Drug Used To Treat Metastatic Islet Cell Cancer of Pancreas

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Streptozocin Market   Streptozocin is an anti-tumor antibiotic consisting of a nitrosourea moiety interposed between a methyl group and glucosamine. Streptozocin is an anti-cancer (antineoplastic or cytotoxic) chemotherapy drug and is classified as an alkylating agent. The United States Food and Drug Administration (FDA) approved this drug to treat pancreatic islet cells cancer. It is used to treat cancer of the pancreas that has gotten worse or spread to other parts of the body and works by slowing or stopping the growth of cancer cells in the body.  Because it carries a high risk of toxicity and rarely cures cancer, its use is generally limited to patients whose cancer cannot be surgically removed. Moreover, in the medical field, it is used as a chemotherapeutic drug to treat certain cancers of the islets of Langerhans, as well as to induce diabetes in experimental animals. Streptozocin-induced diabetic models develop type 1 diabetes, due to the cytotoxic glucose analog stre...

A drug called streptozocin is used to treat pancreatic cancer that has spread to other parts of the body

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    For advanced islet-cell carcinoma, the combination of streptozocin and fluorouracil has become the standard treatment. However, doxorubicin, a drug that is structurally similar to streptozocin but causes less vomiting, has also been shown to be effective against this type of tumor.   We randomly assigned 105 patients with advanced islet-cell carcinoma to one of three treatment regimens in this multicenter trial: streptozocin plus fluorouracil, streptozocin plus doxorubicin, or chlorozotocin alone. The 31 patients who did not respond to the treatment were switched to chlorozotocin alone or one of the combination regimens. What is the purpose of Streptozocin? Streptozocin is used to treat pancreas cancer that has progressed or spread to other parts of the body. Streptozocin belongs to a class of drugs known as alkylating agents. It works by slowing or stopping cancer cell growth in your body. Where can I find streptozotocin? Streptozotocin (STZ) is a naturally occurring...