A drug called streptozocin is used to treat pancreatic cancer that has spread to other parts of the body

 



  For advanced islet-cell carcinoma, the combination of streptozocin and fluorouracil has become the standard treatment. However, doxorubicin, a drug that is structurally similar to streptozocin but causes less vomiting, has also been shown to be effective against this type of tumor.

  We randomly assigned 105 patients with advanced islet-cell carcinoma to one of three treatment regimens in this multicenter trial: streptozocin plus fluorouracil, streptozocin plus doxorubicin, or chlorozotocin alone. The 31 patients who did not respond to the treatment were switched to chlorozotocin alone or one of the combination regimens.

What is the purpose of Streptozocin?

Streptozocin is used to treat pancreas cancer that has progressed or spread to other parts of the body. Streptozocin belongs to a class of drugs known as alkylating agents. It works by slowing or stopping cancer cell growth in your body.

Where can I find streptozotocin?

Streptozotocin (STZ) is a naturally occurring chemical derived from Streptomyces achromogenes that is particularly toxic to the pancreatic insulin-producing beta cells in mammals.

 

  Streptozocin was discovered to be selectively toxic to pancreatic islet beta cells, which normally regulate blood glucose levels by producing the hormone insulin. This suggested that the drug could be used as an animal model of diabetes and as a medical treatment for beta-cell cancers. The National Cancer Institute investigated the use of streptozocin in cancer chemotherapy in the 1960s and 1970s. In November 1976, Upjohn applied to the FDA for approval of streptozocin as a treatment for pancreatic islet cell cancer, and approval was granted in July 1982. The drug was later marketed under the brand name Zanosar.

  More recently, a growing body of research has shown that insulin signaling dysfunction in type 2 diabetes significantly increases the risk of cognitive impairment and Alzheimer's disease (AD) progression. On this basis, direct administration of STZ into the brain (i.e., intracerebroventricular (ICV) infusion) has been used to develop an animal model of brain insulin resistance in rodents to mimic the pathophysiology of sporadic AD, which is the most common type of AD in humans.

Paperblog

Comments

Post a Comment

Popular posts from this blog

Total Disc Replacement complete details Of Competitive Landscape Executive Summary Development in next decade

Image
    Total disc replacement is a type of back/spine surgery in which an artificial replacement device is used to replace a damaged or degenerated disc in the lumbar or cervical region. A disc replacement, also known as an artificial disc, is a device implanted in the spine that performs the same function as a normal disc in the human body. A total disc replacement , as the name implies, is a procedure that involves the complete or partial exclusion of the disc tissue in order to implant a replacement device into the space between the vertebrae. The prostheses help to maintain spinal curvature and flexibility while reducing or possibly eliminating pain.   Cervical total disc replacement (CTDR) surgery is used to treat patients with degenerative disc disease (DDD). The most common cause of DDD in the cervical region of the spine is neck pain. For the treatment of DDD, a cervical disc replacement procedure is performed in which the degenerated disc is surgically removed and...
Read more

Dengue Vaccines development and progress towards vaccine has increased over the past few years

Image
    Dengue fever is a tropical disease spread by mosquitos that are caused by the dengue virus. 3 to 14 days after infection, symptoms appear. A high fever, headache, vomiting, muscle, and joint pains, and a distinct skin rash are all potential symptoms. In most cases, recovery takes two to seven days. In a small percentage of cases, the disease progresses to dengue hemorrhagic fever, which causes bleeding, low levels of blood platelets, and blood plasma leakage, or to dengue shock syndrome, which causes dangerously low blood pressure.   Dengue is spread by several Aides genus female mosquitoes, most notably Aides. The virus has five serotypes; infection with one type usually results in lifelong immunity to that type but only temporary immunity to the others. Subsequent infection with a different type raises the possibility of severe complications. . Dengue vaccines are a vaccine used to protect humans from dengue fever to confirm the diagnosis, a number of tests are ava...
Read more

Marine electronics are electronic devices specifically designed for use in marine environments

Image
    Marine electronics are electronic devices that are specifically designed for use in the marine environment. Radar systems, SONAR, navigation, and communication systems are among the electronics required to carry out various maritime operations effectively. Growing oceanic trade activities and defense sector demand are expected to generate the massive potential for marine electronics during the forecast period.     How do electronic boats function? Most electronic devices come with connectors and cables, which are bundles of colored wires inside a common insulator that you connect to the power and other electronics on your boat. Two of the wires are connected to the power supply. Others connect to NMEA ports, which allow the device to share data with other units.        Marine electronics are machines and electronics that are designed and developed for the marine industry, such as chart plotters, marine VHF radios, marine radar, and others. Aq...
Read more